Article

Oncometabolite R-2 hydroxyglutarate aids the inflammatory transformation of peritumoral astrocytes

2021-07-26

Abstract excerpt

<title>Abstract</title> <p>Reactive transformation of astrocytes in IDH wild-type glioma contribute to anti-tumor immunity and support pro-oncogenic signaling. The role of intra- and peritumoral astrocytes in IDH1/2 mutated glioma, a prognostically beneficial subgroup with oncogene-driven enrichment of R-2-hydroxygluterate (2-HG) remains sparsely explored. Here, we characterized the transcriptomic signature of ID...

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Literature Corpus work: ad4ffe46-fd94-596f-8777-884ccf1321ad
DOI: 10.21203/rs.3.rs-720962/v1

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