Article
D-2-Hydroxyglutarate in Glioma Biology.
Cells - 7 Sept 2021
Chou Fu-Ju, Liu Yang, Lang Fengchao, Yang Chunzhang
Abstract excerpt
Isocitrate dehydrogenase (IDH) mutations are common genetic abnormalities in glioma, which result in the accumulation of an "oncometabolite", D-2-hydroxyglutarate (D-2-HG). Abnormally elevated D-2-HG levels result in a distinctive pattern in cancer biology, through competitively inhibiting α-ketoglutarate (α-KG)/Fe(II)-dependent dioxgenases (α-KGDDs). Recent studies have revealed that D-2-HG affects DNA/histone...
Topics
Join the communities discussing this publication.