Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Factor VNew Brunswick: Ala221-to-Val substitution results in reduced cofactor activity

1 Sept 1995

Abstract excerpt

We have characterized the factor V protein and cDNA of a patient displaying factor V deficiency (parahemophilia) and correlated the reduced activity with a missense mutation of Ala221-to-Val. Plasma from the subject individual (C1) presented reduced factor V antigen (39% of normal) that displayed reduced activity (approximately 26% of normal). Factor V purified from this individual by standard techniques shows...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation and Thrombosis Mechanisms
Share to Hemophilia Treatment and Research

Source

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 7655011
DOI: 10.1182/blood.v86.5.1820.bloodjournal8651820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Factor VNew Brunswick: Ala221-to-Val substitution results in reduced cofactor activityPMID 7655011Read ↗

Factor V New Brunswick: Ala221Val associated with FV deficiency reproduced in vitro and functionally characterized.Semantic proximity Read ↗

Factor V deficiency.Semantic proximity Read ↗

Factor V haemostatic diathesis impairing thrombin activation, membrane binding and circulating antigen level due to a novel compound heterozygous mutation, Leu1821Ser and Gly2192Cys.Semantic proximity Read ↗

Severe coagulation factor V deficiency caused by a 4 bp deletion in the factor V geneSemantic proximity Read ↗

A novel factor V compound heterozygous mutation associated with thrombosis (Y1961C; FV-Kanazawa, together with 1982_1983del).Semantic proximity Read ↗

[A novel mutation causes congenital factor V deficiency].Semantic proximity Read ↗

Purification and characterization of factor VII 304-Gln: a variant molecule with reduced activity isolated from a clinically unaffected male.Semantic proximity Read ↗

Purification and characterization of factor VIII 372-Cys: a hypofunctional cofactor from a patient with moderately severe hemophilia A.Semantic proximity Read ↗

Homozygous factor V splice site mutation associated with severe factor V deficiency.Semantic proximity Read ↗

Leu 697-->Val mutation in mature von Willebrand factor is responsible for type IIB von Willebrand disease.Semantic proximity Read ↗

Functional mapping of the A2 domain from human factor VIII.Semantic proximity Read ↗

Factors XWenatchee I and II: compound heterozygosity involving two variant proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.