Article
iRGD-liposomes enhance tumor delivery and therapeutic efficacy of antisense oligonucleotide drugs against primary prostate cancer and bone metastasis
2021-01-09
Abstract excerpt
Nucleotide-based drugs, such as antisense oligonucleotides (ASOs), have unique advantages in treating human diseases as they provide virtually unlimited ability to target any gene. However, their clinical translation faces many challenges, one of which is poor delivery to the target tissue in vivo . This problem is particularly evident in solid tumors. Here, we functionalized liposomes with a tumor-homing and -pe...
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Identifiers and source
- Literature Corpus work
- ad32bad7-ccb9-5131-9ef0-e19369ae7577
- DOI
- 10.1101/2021.01.08.426005