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Article

Pathogenesis and treatment of prostate cancer bone metastases: targeting the lethal phenotype.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Nov 2005

Loberg Robert D, Logothetis Christopher J, Keller Evan T, Pienta Kenneth J

Abstract excerpt

Traditionally, prostate cancer treatment, as well as all cancer treatment, has been designed to target the tumor cell directly via various hormonal and chemotherapeutic agents. Recently, the realization that cancer cells exist in complex microenvironments that are essential for the tumorigenic and metastatic potential of the cancer cells is starting the redefine the paradigm for cancer therapy. The propensity of...

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Identifiers

PMID: 16278478
DOI: 10.1200/JCO.2005.03.0841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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