Article

mTOR inhibition enhances delivery and activity of antisense oligonucleotides in uveal melanoma cells

2021-09-29

Abstract excerpt

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Due to a lack of effective treatments, patients with metastatic disease have a median survival time of 6-12 months. We recently demonstrated that the SAMMSON long non-coding RNA (lncRNA) is essential for uveal melanoma cell survival and that antisense oligonucleotide (ASO)-mediated silencing of SAMMSON impaired cell viability and tu...

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Literature Corpus work: 12a7d3b6-696e-5d99-929c-88d930f7a111
DOI: 10.1101/2021.09.29.462324

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