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Article

Targeted induction of endogenous NKX3‐1 by small activating RNA inhibits prostate tumor growth

8 Jul 2013

Abstract excerpt

BACKGROUND: RNA activation (RNAa) is a small RNA-mediated gene regulation mechanism by which expression of a particular gene can be induced by targeting its promoter using small double-stranded RNA also known as small activating RNA (saRNA). We used saRNA as a molecular tool to examine NKX3-1's role as a tumor suppressor and tested in vitro and in vivo antitumor effects of NKX3-1 induction by saRNA. MATERIALS AND...

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PMID: 23836514
DOI: 10.1002/pros.22709

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