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Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression

24 Oct 2024

Abstract excerpt

Viral infection leads to heterogeneous cellular outcomes ranging from refractory to abortive and fully productive states. Single cell transcriptomics enables a high resolution view of these distinct post-infection states. Here, we have interrogated the host-pathogen dynamics following reactivation of Epstein-Barr virus (EBV). While benign in most people, EBV is responsible for infectious mononucleosis, up to 2%...

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PMID: 39446925
DOI: 10.1371/journal.ppat.1012341

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