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Article

Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents.

Nature reviews. Cancer - 1 Apr 2010

Sharma Sreenath V, Haber Daniel A, Settleman Jeff

Abstract excerpt

Efforts to discover new cancer drugs and predict their clinical activity are limited by the fact that laboratory models to test drug efficacy do not faithfully recapitulate this complex disease. One important model system for evaluating candidate anticancer agents is human tumour-derived cell lines. Although cultured cancer cells can exhibit distinct properties compared with their naturally growing counterparts,...

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PMID: 20300105
DOI: 10.1038/nrc2820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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