Back to search

Article

A quantitative chemotherapy genetic interaction map reveals new factors associated with PARP inhibitor resistance

2017-08-03

Abstract excerpt

<h4>SUMMARY</h4> Nearly every cancer patient is treated with chemotherapy yet our understanding of factors that dictate response and resistance to such agents remains limited. We report the generation of a quantitative chemical-genetic interaction map in human mammary epithelial cells that charts the impact of knockdown of 625 cancer and DNA repair related genes on sensitivity to 29 drugs, covering all classes of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5bfb7f16-2aad-5d03-8c8f-591b4160be90
DOI
10.1101/171918
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A quantitative chemotherapy genetic interaction map reveals new factors associated with PARP inhibitor resistanceDOI 10.1101/171918
A Quantitative Chemotherapy Genetic Interaction Map Reveals Factors Associated with PARP Inhibitor ResistanceSemantic proximity
Quantitative <i>in vivo</i> analyses reveal a complex pharmacogenomic landscape in lung adenocarcinomaSemantic proximity
PARP1 impact on DNA repair of platinum adducts: Preclinical and clinical read-outsSemantic proximity
Mapping genetic interactions in cancer: a road to rational combination therapiesSemantic proximity
Enhancing cisplatin drug sensitivity through PARP3 inhibition: The influence on PDGF and G-coupled signal pathways in cancer.Semantic proximity
The Mutational Landscape of Cancer's Vulnerability to Ionizing Radiation.Semantic proximity
DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implicationsSemantic proximity
DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategiesSemantic proximity
Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-WideSemantic proximity
Clinical approaches to overcome PARP inhibitor resistanceSemantic proximity
Targeting DNA damage response pathways in tumor drug resistance: Mechanisms, clinical implications, and future directionsSemantic proximity
A genetic map of the response to DNA damage in human cellsSemantic proximity
Select a neighboring publication to make it the new centre.