Article

25-Hydroxyl-cholesterol Binds and Enhance Anti-viral Effects of Zebrafish Monomeric C-reactive Proteins

2018-07-18

Abstract excerpt

C-reactive proteins (CRP) are among the faster acute-phase inflammation-responses coded by one gene in humans ( hcrp ) and seven genes ( crp1-7 ) in zebrafish ( Danio rerio ). In this study, preferential 25-hydroxycholesterol (25HOCh) binding to zebrafish CRP1-7 compared to other lipids were predicted by in silico docking and confirmed by solid-phase binding-assays. In addition, 25HOCh enhanced methyl-betacycl...

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Literature Corpus work: acfa7e31-2e63-5dd2-b262-4f4f141f0162
DOI: 10.1101/371856

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