Article
Opposing effects of monomeric and pentameric C-reactive protein on endothelial progenitor cells.
Basic research in cardiology - 1 Sept 2011
Ahrens I, Domeij H, Eisenhardt S U, Topcic D, Albrecht M, Leitner E, Viitaniemi K, Jowett J B, Lappas M, Bode C, Haviv I, Peter K
Abstract excerpt
C-reactive protein (CRP) has been linked to the pathogenesis of atherosclerosis. The dissociation of native, pentameric (p)CRP to monomeric (m)CRP on the cell membrane of activated platelets has recently been demonstrated. The dissociation of pCRP to mCRP may explain local pro-inflammatory reactions at the site of developing atherosclerotic plaques. As a biomarker, pCRP predicts cardiovascular adverse events and...
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