Article

Possibility of hypoxanthine oxidation mediated by mouse aldehyde oxidase in vivo

2026-06-18

Abstract excerpt

<title>Abstract</title> <p> Type 1 xanthinuria is characterized by elevated levels of xanthine in blood and urine but near absent amounts of uric acid. In humans, xanthine oxidoreductase (XOR) gene ( <italic>XDH</italic> ) mutations in type 1 xanthinuria do not affect lifespan whereas <italic>Xdh</italic> knockout ( <italic>Xdh</italic> KO) mice die young. High activity allele of hypoxanthine phosphoribosy...

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Literature Corpus work: ace9ddf4-fdc2-5242-a78e-6f655aef23c7
DOI: 10.21203/rs.3.rs-9288396/v1

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