Article

Repurposing celecoxib for ovarian cancer treatment by targeting survivin signaling

2023-01-06

Abstract excerpt

<title>Abstract</title> <p>Background Ovarian cancer is the leading cause of deaths among gynecologic cancers. With a five-year survival rate just slightly above 45% and high rates of chemo-toxicity and chemo-resistance, the search for novel, more effective, and less toxic therapeutic approaches is thus imperative. In the current study, we aimed to explore the potential antitumor effect of a COX-2 inhibitor, cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eacebb04-652d-554b-892f-169d35c6391f
DOI: 10.21203/rs.3.rs-2429733/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Repurposing celecoxib for ovarian cancer treatment by targeting survivin signalingDOI 10.21203/rs.3.rs-2429733/v1Read

Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin SignalingSemantic proximity Read

BFGF Mitigates CTX-Induced Ovarian Cytotoxicity via SERPINE1/HIF-1 and Nrf-2/HO-1 Signaling PathwaysSemantic proximity Read

COX-2-Dependent and COX-2-Independent Mode of Action of Celecoxib in Human Liver Cancer CellsSemantic proximity Read

Celecoxib induces apoptosis but up-regulates VEGF via endoplasmic reticulum stress in human colorectal cancer in vitro and in vivoSemantic proximity Read

Chemoresistance in human ovarian cancer: the role of apoptotic regulatorsSemantic proximity Read

A systems biology-based study to assess the effects of TNF-α ± apigenin in triple-negative breast cancer cell lineSemantic proximity Read

Alisol A attenuates malignant phenotypes of colorectal cancer cells by inactivating PI3K/Akt signalingSemantic proximity Read

Targeting Signaling Pathways in Epithelial Ovarian CancerSemantic proximity Read

Resveratrol Targets a Variety of Oncogenic and Oncosuppressive Signaling for Ovarian Cancer Prevention and TreatmentSemantic proximity Read

Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor.Semantic proximity Read

Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells.Semantic proximity Read

Unraveling the Anti-Multiple Myeloma Activity of Alisol B 23-Acetate and Its Impact on the P38MAPK Pathway Through Integrated AnalysisSemantic proximity Read