Article

Engineering M1 macrophages with targeting aptamers for enhanced adoptive immunotherapy by modifying the cell surface

2024-04-17

Abstract excerpt

<title>Abstract</title> <p>Macrophages play a critical role in the body's defense against cancer by phagocytosing tumor cells, presenting antigens, and activating adaptive T cells. However, macrophages are intrinsically incapable of delivering targeted cancer immunotherapies. Engineered adoptive cell therapy introduces new targeting and antitumor capabilities by modifying macrophages to enhance the innate immune...

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Literature Corpus work: acd0b33f-ca36-5de0-9774-ea256b15898b
DOI: 10.21203/rs.3.rs-4250998/v1

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