Article

Examining the Association between Mitochondrial Genome Variation and Coronary Artery Disease

2022-02-10

Abstract excerpt

<h4>Background</h4> Large-scale genome-wide association studies have identified hundreds of single-nucleotide variants (SNVs) significantly associated with coronary artery disease (CAD). However, collectively, these explain <20% of the heritability. <h4>Hypothesis</h4> Here, we hypothesize that mitochondrial (MT) SNVs might present one potential source of this “missing heritability”. <h4>Methods</h4> We analyzed 2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1e1d5c6b-6e7b-5532-80e7-688cf0587ae6
DOI: 10.1101/2022.02.09.22270723

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Examining the Association between Mitochondrial Genome Variation and Coronary Artery DiseaseDOI 10.1101/2022.02.09.22270723Read

Comprehensive analysis of the mitochondrial DNA variants using multivariate covariate and multiple-testing models to enhance reliability reveals potential associations with coronary artery disease traits and dietary preferences.Semantic proximity Read

Mitochondrial Genetics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association.Semantic proximity Read

ASSOCIATION ANALYSIS OF MITOCHONDRIAL HETEROPLASMIC VARIANTS AND CARDIOMETABOLIC TRAITSSemantic proximity Read

Investigating the relationship between mitochondrial genetic variation and cardiovascular-related traits to develop a framework for mitochondrial phenome-wide association studiesSemantic proximity Read

The alterations of mitochondrial DNA in coronary heart disease.Semantic proximity Read

Mitochondrial related variants associated with cardiovascular traitsSemantic proximity Read

Low mitochondrial copy number drives atherogenic cardiovascular disease: evidence from prospective cohort analyses in the UK Biobank combined with Mendelian RandomizationSemantic proximity Read

Association of Metabolic Diseases and Moderate Fat Intake with Myocardial Infarction Risk.Semantic proximity Read

Detecting Rare Variants and Heteroplasmy of Mitochondrial DNA from High-Throughput Sequencing in Patients with Coronary Artery Disease.Semantic proximity Read

Association between peripheral blood cells mitochondrial DNA content and severity of coronary heart diseaseSemantic proximity Read

The aetiology of cardiovascular disease: a role for mitochondrial DNA?Semantic proximity Read

The association between mitochondrial DNA copy number, low-density lipoprotein cholesterol, and cardiovascular disease riskSemantic proximity Read