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Article

Mitochondrial DNA Content Is Linked to Cardiovascular Disease Patient Phenotypes.

Journal of the American Heart Association - 16 Feb 2021

Wei Ruipeng, Ni Ying, Bazeley Peter, Grandhi Sneha, Wang Janet, Li Samuel T, Hazen Stanley L, Wilson Tang W H, LaFramboise Thomas

Abstract excerpt

Background We sought to determine whether mitochondrial DNA (mtDNA) content can be used as markers for 12 key phenotypes among cardiovascular disease patients, and whether these markers are valid across patients with diverse ancestries. Methods and Results DNA was collected from the peripheral blood of 996 cardiovascular disease patients at the Cleveland Clinic. The mtDNA copy number and DNA-level variation were...

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Identifiers

PMID: 33533264
DOI: 10.1161/JAHA.120.018776
PMCID: PMC7955324

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