Article

Free energy and flexibility analysis of autoinhibited human BRAF

2025-08-06

Abstract excerpt

<h4>ABSTRACT</h4> The RAF serine/threonine protein kinases function as direct effectors of RAS in the intracellular transmission of extracellular growth signals, and they are key targets for drug discovery given the high incidence of oncogenic mutations in RAF and other components of this signaling pathway. In its inactive state, RAF is held in an autoinhibited conformation in the cytosol through a combination of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: acc200aa-85a1-54b5-9786-6da3c20da91f
DOI: 10.1101/2025.08.04.668576

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Free energy and flexibility analysis of autoinhibited human BRAFDOI 10.1101/2025.08.04.668576Read

Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.Semantic proximity Read

The stability of R-spine defines RAF inhibitor resistance: A comprehensive analysis of oncogenic BRAF mutants with in-frame insertion of αC-β4 loopSemantic proximity Read

Analyses of the oncogenic BRAFD594G variant reveal a kinase-independent function of BRAF in activating MAPK signaling.Semantic proximity Read

B-Raf autoinhibition in the presence and absence of 14-3-3.Semantic proximity Read

BRAF oncogenic mutants evade autoinhibition through a common mechanism.Semantic proximity Read

Unveiling the Domain-Specific and RAS Isoform-Specific Details of BRAF RegulationSemantic proximity Read

New insights into Raf regulation from structural analyses.Semantic proximity Read

Mutation-specific structural changes in BRAF: understanding dimerization and drug binding for targeted therapy.Semantic proximity Read

Mapping the free energy landscape of K-Ras4B dimerizationSemantic proximity Read

Stabilization of a closed kinase conformation induces RAF dimerization.Semantic proximity Read

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif-mediated asymmetric BRAF dimer.Semantic proximity Read

An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving Disassembly of the Autoinhibited BRAF StateSemantic proximity Read