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Article

Stabilization of a closed kinase conformation induces RAF dimerization.

Cancer discovery - 1 Jul 2013

Abstract excerpt

BRAF inhibitors stabilize a closed, rigid RAF kinase conformation that facilitates dimerization.

Read the complete abstract on PubMed

Topics

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Share to Biosensing Techniques
Share to Cell Line, Tumor
Share to Dimerization
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Conformation

Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Proteins B-raf

Share to raf Kinases

Source

Identifiers

PMID: 23847340
DOI: 10.1158/2159-8290.CD-RW2013-114

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Stabilization of a closed kinase conformation induces RAF dimerization.PMID 23847340Read ↗

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.Semantic proximity Read ↗

Analyses of the oncogenic BRAFD594G variant reveal a kinase-independent function of BRAF in activating MAPK signaling.Semantic proximity Read ↗

The stability of R-spine defines RAF inhibitor resistance: A comprehensive analysis of oncogenic BRAF mutants with in-frame insertion of αC-β4 loopSemantic proximity Read ↗

New insights into Raf regulation from structural analyses.Semantic proximity Read ↗

Allosteric activation of functionally asymmetric RAF kinase dimers.Semantic proximity Read ↗

The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants.Semantic proximity Read ↗

Inhibitors of BRAF dimers using an allosteric site.Semantic proximity Read ↗

Path Forward for RAF Therapies: Inhibition of Monomers and Dimers.Semantic proximity Read ↗

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition.Semantic proximity Read ↗

The importance of Raf dimerization in cell signaling.Semantic proximity Read ↗

Interactome dynamics of RAF1-BRAF kinase monomers and dimers.Semantic proximity Read ↗

Free energy and flexibility analysis of autoinhibited human BRAFSemantic proximity Read ↗

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