Article
Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.
Nature communications - 25 Jan 2022
Martinez Fiesco Juliana A, Durrant David E, Morrison Deborah K, Zhang Ping
Abstract excerpt
RAF kinases are essential effectors of RAS, but how RAS binding initiates the conformational changes needed for autoinhibited RAF monomers to form active dimers has remained unclear. Here, we present cryo-electron microscopy structures of full-length BRAF complexes derived from mammalian cells: autoinhibited, monomeric BRAF:14-3-32:MEK and BRAF:14-3-32 complexes, and an inhibitor-bound, dimeric BRAF2:14-3-32...
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