Article

Single-domain antibody delivery using an mRNA platform protects against lethal doses of botulinum neurotoxin A

2022-10-30

Abstract excerpt

<h4>ABSTRACT</h4> Single-domain antibodies (sdAbs, VHHs, or nanobodies) are a promising tool for the treatment of both infectious and somatic diseases. Their small size greatly simplifies any genetic engineering manipulations. Such antibodies have the ability to bind hard-to-reach antigenic epitopes through long parts of the variable chains, the third complementarity-determining regions (CDR3s). VHH fusion with t...

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Literature Corpus work: 2810248c-76d4-5fae-80f4-d7564335d2a9
DOI: 10.1101/2022.10.29.514343

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