Article

Controllable self-replicating RNA vaccine delivered intradermally elicits predominantly cellular immunity

2022-09-06

Abstract excerpt

<h4>Summary</h4> Intradermal delivery of self-replicating RNA (srRNA) is a promising vaccine platform. Considering that human skin temperature is around 33°C, lower than core body temperature of 37°C, we have developed an srRNA that functions optimally at skin temperature and is inactivated at or above 37°C as a safety switch. This temperature- c ontrollable srRNA (c-srRNA), when tested as an intradermal vaccine...

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Identifiers and source

Literature Corpus work: 49eb7429-16a3-526b-94b8-39c61d096a2d
DOI: 10.1101/2022.09.05.506686

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