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Article

Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates

9 Jan 2025

Abstract excerpt

mRNA delivered using lipid nanoparticles (LNPs) has become an important subunit vaccine modality, but mechanisms of action for mRNA vaccines remain incompletely understood. Here, we synthesized a metal chelator-lipid conjugate enabling positron emission tomography (PET) tracer labeling of LNP/mRNA vaccines for quantitative visualization of vaccine trafficking in live mice and non-human primates (NHPs). Following...

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Identifiers

PMID: 39797396
DOI: 10.1016/j.ymthe.2025.01.008

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