Article

Type IV pilus length determines virulence by regulating a hidden subpopulation of non-contributing filaments

2026-04-04

Abstract excerpt

Many clinically important bacterial pathogens, including Pseudomonas , Vibrio , Neisseria , and Acinetobacter species, employ dynamic extracellular appendages called type IV pili (T4P) to facilitate virulence through cyclical extension and retraction of pilus filaments. To dissect how T4P dynamics govern pathogenesis, we engineered a genetic system to precisely tune pilus length across a continuum. We demonstr...

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Literature Corpus work: ac70036e-686b-5a4b-8621-b5b09c2a1d93
DOI: 10.64898/2026.04.02.716181

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