Article
Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jun 2015
Persat Alexandre, Inclan Yuki F, Engel Joanne N, Stone Howard A, Gitai Zemer
Abstract excerpt
Bacteria have evolved a wide range of sensing systems to appropriately respond to environmental signals. Here we demonstrate that the opportunistic pathogen Pseudomonas aeruginosa detects contact with surfaces on short timescales using the mechanical activity of its type IV pili, a major surface adhesin. This signal transduction mechanism requires attachment of type IV pili to a solid surface, followed by pilus...
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