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Comparative transcriptional analysis identifies genes associated with the attenuation of Theileria parva infected cells after long-term in vitro culture

2023-11-28

Abstract excerpt

<title>Abstract</title> <p>Autologous administration of attenuated Theileria parva-infected cells induces immunity to T. parva in cattle. The mechanism of attenuation, however, is largely unknown. Here, we used RNA sequencing of pathogenic and attenuated T. parva-infected T-cells to elucidate the transcriptional changes underpinning attenuation. We observed differential expression of several host genes, including...

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Literature Corpus work
ac67fc88-1661-5298-bff4-8d91f758059e
DOI
10.21203/rs.3.rs-3514623/v1
Open publication

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Comparative transcriptional analysis identifies genes associated with the attenuation of Theileria parva infected cells after long-term in vitro cultureDOI 10.21203/rs.3.rs-3514623/v1
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