Article
Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes.
International journal for parasitology - 1 Jan 2006
Shiels Brian, Langsley Gordon, Weir William, Pain Arnab, McKellar Sue, Dobbelaere Dirk
Abstract excerpt
The apicomplexan parasites Theileria annulata and Theileria parva cause severe lymphoproliferative disorders in cattle. Disease pathogenesis is linked to the ability of the parasite to transform the infected host cell (leukocyte) and induce uncontrolled proliferation. It is known that transformation involves parasite dependent perturbation of leukocyte signal transduction pathways that regulate apoptosis,...
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