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Article

Phenotypic and genotypic alterations associated with the attenuation of a Theileria annulata vaccine cell line from Turkey.

Vaccine - 1 Apr 1998

Somerville R P, Littlebury P, Pipano E, Brown C G, Shkap V, Adamson R E, Oliver R A, Glass E J, Hall F R

Abstract excerpt

Attenuated vaccines, produced by prolonged in vitro culture of the macroschizont stage of the life-cycle, are the main method of controlling Theileria annulata infections. Little is known about the mechanism(s) of attenuation. Here we present data from a Turkish cell line demonstrating that attenuation is associated with reduced ability to differentiate into microschizonts and a reduction in matrix...

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PMID: 9569467
DOI: 10.1016/s0264-410x(97)84509-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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