Article

Structural bases for the Charcot–Marie–Tooth disease induced by single amino acid substitutions of myelin protein zero

2023-04-13

Abstract excerpt

Myelin protein zero (MPZ or P0) is a major transmembrane protein expressed in peripheral compact myelin and functions to glue membranes to form multiple layered membranes characteristic of myelin. Intermembrane adhesion is mediated by homophilic interactions between the extracellular domains (ECDs) of MPZ molecules. Single amino acid substitutions in an ECD cause demyelinating neuropathy, known as Charcot–Marie–To...

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Literature Corpus work: ac61daf6-fd9b-592d-8a9f-b735ba8944fe
DOI: 10.1101/2023.04.12.536520

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