Article

Neuropathy-related mutations alter the membrane binding properties of the human myelin protein P0 cytoplasmic tail

2019-01-30

Abstract excerpt

Schwann cells myelinate selected axons in the peripheral nervous system (PNS) and contribute to fast saltatory conduction via the formation of compact myelin, in which water is excluded from between tightly adhered lipid bilayers. Peripheral neuropathies, such as Charcot-Marie-Tooth disease (CMT) and Dejerine-Sottas syndrome (DSS), are incurable demyelinating conditions that result in pain, decrease in muscle mas...

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Literature Corpus work: 9a158326-1083-5267-9482-a2f3bb986c51
DOI: 10.1101/535013

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