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Article

In silico and in vitro effects of the I30T mutation on myelin protein zero instability in the cell membrane.

Cell biology international - 1 Feb 2020

Ghanavatinejad Fatemeh, Pourteymourfard-Tabrizi Zahra, Mahnam Karim, Doosti Abbas, Mehri-Ghahfarrokhi Ameneh, Pourhadi Masoumeh, Azimeh Hosseini Sayedeh, Hashemzadeh Chaleshtori Morteza, Soltanzadeh Payam, Jami Mohammad-Saeid

Abstract excerpt

Charcot-Marie-Tooth (CMT) diseases are a heterogeneous group of genetic peripheral neuropathies caused by mutations in a variety of genes, which are involved in the development and maintenance of peripheral nerves. Myelin protein zero (MPZ) is expressed by Schwann cells, and MPZ mutations can lead to primarily demyelinating polyneuropathies including CMT type 1B. Different mutations demonstrate various forms of...

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PMID: 31769568
DOI: 10.1002/cbin.11268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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