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Article

Phenotypic clustering in MPZ mutations.

Brain : a journal of neurology - 1 Feb 2004

Shy Michael E, Jáni Agnes, Krajewski Karen, Grandis Marina, Lewis Richard A, Li Jun, Shy Rosemary R, Balsamo Janne, Lilien Jack, Garbern James Y, Kamholz John

Abstract excerpt

Myelin protein zero (MPZ) is a member of the immunoglobulin gene superfamily with single extracellular, transmembrane and cytoplasmic domains. Homotypic interactions between extracellular domains of MPZ adhere adjacent myelin wraps to each other. MPZ is also necessary for myelin compaction since mice which lack MPZ develop severe dysmyelinating neuropathies in which compaction is dramatically disrupted. MPZ...

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Source

Identifiers

PMID: 14711881
DOI: 10.1093/brain/awh048

Genes

MPZ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phenotypic clustering in MPZ mutations.PMID 14711881Read ↗

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