Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development

23 Apr 2024

Abstract excerpt

While dysfunction and death of light-detecting photoreceptor cells underlie most inherited retinal dystrophies, knowledge of the species-specific details of human rod and cone photoreceptor cell development remains limited. Here, we generated retinal organoids carrying retinal disease-causing variants in NR2E3, as well as isogenic and unrelated controls. Organoids were sampled using single-cell RNA sequencing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38652563
DOI: 10.1172/jci173892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal developmentPMID 38652563Read ↗

Loss of NR2E3 disrupts rod photoreceptor cell maturation causing a fate switch late in human retinal developmentSemantic proximity Read ↗

Specific photoreceptor cell fate pathways are differentially altered in NR2E3-associated diseasesSemantic proximity Read ↗

Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related featuresSemantic proximity Read ↗

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution.Semantic proximity Read ↗

Cell types of the human retina and its organoids at single-cell resolution: developmental convergence, transcriptomic identity, and disease mapSemantic proximity Read ↗

Nuclear Receptor Subfamily 2 Group E Member 3 (NR2E3): Role in Retinal Development and DiseaseSemantic proximity Read ↗

Generation of human neural retina transcriptome atlas by single cell RNA sequencingSemantic proximity Read ↗

Retinal Organoid Single-Cell Transcriptomics Reveals Effects of PRPF31 Mutation on Early Müller Glial Activation and Progressive Photoreceptor DegenerationSemantic proximity Read ↗

Human retinal organoid single-cell atlas allows to reconstruct retinal development at high resolution and identify nature restricted transcriptional states in vitroSemantic proximity Read ↗

USH2A-Mutated Human Retinal Organoids Model Rod-Cone Dystrophy.Semantic proximity Read ↗

Specialization of the photoreceptor transcriptome by <i>Srrm3</i> -dependent microexons is required for outer segment maintenance and visionSemantic proximity Read ↗

Modeling autosomal dominant retinitis pigmentosa by using patient-specific retinal organoids with a class-3 RHO mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.