Article

Cell types of the human retina and its organoids at single-cell resolution: developmental convergence, transcriptomic identity, and disease map

2019-07-16

Abstract excerpt

<h4>Summary</h4> How closely human organoids recapitulate cell-type diversity and cell-type maturation of their target organs is not well understood. We developed human retinal organoids with multiple nuclear and synaptic layers. We sequenced the RNA of 158,844 single cells from these organoids at six developmental time points and from the periphery, fovea, pigment epithelium and choroid of light-responsive adult...

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Literature Corpus work: 041bb6ec-a1c7-5567-a14e-7563616fd5af
DOI: 10.1101/703348

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