Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution.

doi:10.1016/j.cell.2020.08.013

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Article

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution.

Cell - 17 Sept 2020

Cowan Cameron S, Renner Magdalena, De Gennaro Martina, Gross-Scherf Brigitte, Goldblum David, Hou Yanyan, Munz Martin, Rodrigues Tiago M, Krol Jacek, Szikra Tamas, Cuttat Rachel, Waldt Annick, Papasaikas Panagiotis, Diggelmann Roland, Patino-Alvarez Claudia P, Galliker Patricia, Spirig Stefan E, Pavlinic Dinko, Gerber-Hollbach Nadine, Schuierer Sven, Srdanovic Aldin, Balogh Marton, Panero Riccardo, Kusnyerik Akos, Szabo Arnold, Stadler Michael B, Orgül Selim, Picelli Simone, Hasler Pascal W, Hierlemann Andreas, Scholl Hendrik P N, Roma Guglielmo, Nigsch Florian, Roska Botond

Abstract excerpt

Human organoids recapitulating the cell-type diversity and function of their target organ are valuable for basic and translational research. We developed light-sensitive human retinal organoids with multiple nuclear and synaptic layers and functional synapses. We sequenced the RNA of 285,441 single cells from these organoids at seven developmental time points and from the periphery, fovea, pigment epithelium and...

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PMID: 32946783
DOI: 10.1016/j.cell.2020.08.013
PMCID: PMC7505495

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