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Article

Single-Cell Transcriptomic Dataset of RPGR-associated Retinitis Pigmentosa Patient-Derived Retinal Organoids.

Scientific data - 26 Nov 2024

Li Ting, Ma Yuting, Cheng Yun, Zhao Yingke, Qiu Zhixu, Liu Hongli, Zhang Daowei, Wu Jiawen, Li Junfeng, Zhang Shenghai, Wu Jihong

Abstract excerpt

X-linked retinitis pigmentosa (XLRP) is a severe hereditary retinal disorder marked by progressive vision loss due to photoreceptor dysfunction. The retinitis pigmentosa GTPase regulator (RPGR) gene, responsible for most XLRP cases, encodes a protein crucial for the transport of visual signal proteins between the photoreceptor inner and outer segments. However, the mechanism of RPGR mutation causing photoreceptor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39592612
DOI: 10.1038/s41597-024-04124-z
PMCID: PMC11599861

Genes

RPGR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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