Article

Maternal Western-Style Diet Impairs Bone Marrow Development and Drives a Hyperinflammatory Phenotype in Hematopoietic Stem and Progenitor Cells in Fetal Rhesus Macaques

2021-04-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Maternal obesity adversely impacts the in utero metabolic environment and offspring’s health, but its effect on fetal hematopoiesis and immune cell development remains incompletely understood, particularly in models that resemble human development. <h4>Methods</h4> We studied gestational day 130-135 fetuses derived from rhesus macaque dams chronically exposed to a high-fat...

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Literature Corpus work: ac5c3b0c-9b3a-5ba3-9b1d-407504fe9271
DOI: 10.1101/2021.04.26.441556

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