Maternal high-fat diet disrupts placental spliceosome pathways independent of obesity phenotype: time-series transcriptome analysis during mid-to-late gestation in rats.

Abstract excerpt

Maternal obesity is known to adversely affect fetal development, with placental transcriptional dysregulation being one of the key mechanisms. However, the effect of a maternal high-fat diet (HFD) on dynamic placental gene expression, particularly in the context of obesity propensity, remains poorly understood. This study aimed to investigate the impact of a maternal HFD on time-dependent placental transcriptome...

Topics

• Animals
• Female
• Pregnancy
• Spliceosomes
• Placenta
• Diet, High-Fat
• Rats, Sprague-Dawley
• Rats
• Obesity
• Transcriptome
• Gene Expression Profiling