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Article

Genetically modified mouse models for premature ovarian failure (POF).

Molecular and cellular endocrinology - 5 Feb 2010

Jagarlamudi Krishna, Reddy Pradeep, Adhikari Deepak, Liu Kui

Abstract excerpt

Premature ovarian failure (POF) is a complex disorder that affects approximately 1% of women. POF is characterized by the depletion of functional ovarian follicles before the age of 40 years, and clinically, patients may present with primary amenorrhea or secondary amenorrhea. Although some genes have been hypothesized to be candidates responsible for POF, the etiology of most of the cases is idiopathic, with the...

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Identifiers

PMID: 19643165
DOI: 10.1016/j.mce.2009.07.016

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