Article

Restoring Mitochondrial Quantity and Quality to Reverse Warburg Effect and Drive Tumor Differentiation

2024-12-13

Abstract excerpt

<title>Abstract</title> <p>Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors, and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis...

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Literature Corpus work: ac427bf8-5c76-5feb-9f90-4ab6216f6b1d
DOI: 10.21203/rs.3.rs-5494402/v1

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