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Article

Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress.

Free radical biology & medicine - 1 Dec 2011

Schneider Lonnie, Giordano Samantha, Zelickson Blake R, S Johnson Michelle, A Benavides Gloria, Ouyang Xiaosen, Fineberg Naomi, Darley-Usmar Victor M, Zhang Jianhua

Abstract excerpt

Cell differentiation is associated with changes in metabolism and function. Understanding these changes during differentiation is important in the context of stem cell research, cancer, and neurodegenerative diseases. An early event in neurodegenerative diseases is the alteration of mitochondrial function and increased oxidative stress. Studies using both undifferentiated and differentiated SH-SY5Y neuroblastoma...

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Identifiers

PMID: 21945098
DOI: 10.1016/j.freeradbiomed.2011.08.030
PMCID: PMC3208787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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