Article

Site-specific Integration of Therapeutic-length Genes using TIVID System

2025-10-16

Abstract excerpt

<title>Abstract</title> <p>Site-specific integration of large genes in human primary stem cells remains a significant challenge in gene therapy, particularly for treating multiallelic diseases. Gene editing efficiency in primary stem cells is heavily influenced by the delivery strategy, which often faces issues with programmability, efficiency, and specificity. Here, we developed a dual-viral delivery system, Tar...

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Literature Corpus work: ac3fe711-39d3-58f8-980e-c8eaf6d6b352
DOI: 10.21203/rs.3.rs-7154020/v1

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