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Article

Targeted genome modifications using integrase-deficient lentiviral vectors.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Dec 2007

Cornu Tatjana I, Cathomen Toni

Abstract excerpt

Gene correction aims at repairing a defective gene directly in the cellular genome, which warrants tissue-specific and sustained expression of the repaired gene through its endogenous promoter. We have developed a novel system based on integrase-deficient lentiviral vectors (IDLVs) that allows us...

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PMID: 17998901
DOI: 10.1038/sj.mt.6300345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17998901-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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