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Unraveling the Causal Association Between microRNAs and Ulcerative Colitis: A Multi-Stage Mendelian Randomization Study with External Validation

2026-02-05

Abstract excerpt

<title>Abstract</title> <p>Background Circulating microRNAs (miRNAs) are frequently dysregulated in ulcerative colitis (UC), yet whether these alterations represent causes or consequences of the disease remains unclear. This study aimed to systematically investigate the causal effect of plasma miRNAs on UC risk using a comprehensive multi-stage Mendelian randomization (MR) framework. Methods We employed a two-s...

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Literature Corpus work
ac27a31a-9731-534a-b362-b17d8c8021c1
DOI
10.21203/rs.3.rs-8634046/v1
Open publication

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Unraveling the Causal Association Between microRNAs and Ulcerative Colitis: A Multi-Stage Mendelian Randomization Study with External ValidationDOI 10.21203/rs.3.rs-8634046/v1
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