Integrated analysis of Mendelian Randomization and Bayesian colocalization reveals bidirectional causal association between inflammatory bowel disease and psoriasis

Abstract excerpt

Background Observational studies have suggested an association between inflammatory bowel disease [IBD] and psoriasis. However, the detailed genetic basis, causality, and direction of this association remain unclear.Methods Bidirectional two-sample Mendelian Randomization [MR] analysis was conducted using summary statistics from published genome-wide association studies. Bayesian Colocalization and multivariable...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Inflammatory Bowel Disease
• Share to Psoriasis: Treatment and Pathogenesis
• Share to Spondyloarthritis Studies and Treatments