The causal relationship between inflammatory bowel disease and primary biliary cholangitis: A bidirectional two-sample Mendelian randomization study.

Abstract excerpt

The cause-and-effect relationship between inflammatory bowel disease (IBD) and primary biliary cholangitis (PBC) has not been fully elucidated. Thus, this study explored their causal relationship through bidirectional 2-sample Mendelian randomization (MR). Genome-wide association studies were used to obtain data. Single-nucleotide polymorphisms (SNPs) closely related to IBD (including ulcerative colitis [UC] and...

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