Article
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.
Nature genetics - 1 Feb 2018
Coll Francesc, Phelan Jody, Hill-Cawthorne Grant A, Nair Mridul B, Mallard Kim, Ali Shahjahan, Abdallah Abdallah M, Alghamdi Saad, Alsomali Mona, Ahmed Abdallah O, Portelli Stephanie, Oppong Yaa, Alves Adriana, Bessa Theolis Barbosa, Campino Susana, Caws Maxine, Chatterjee Anirvan, Crampin Amelia C, Dheda Keertan, Furnham Nicholas, Glynn Judith R, Grandjean Louis, Minh Ha Dang, Hasan Rumina, Hasan Zahra, Hibberd Martin L, Joloba Moses, Jones-López Edward C, Matsumoto Tomoshige, Miranda Anabela, Moore David J, Mocillo Nora, Panaiotov Stefan, Parkhill Julian, Penha Carlos, Perdigão João, Portugal Isabel, Rchiad Zineb, Robledo Jaime, Sheen Patricia, Shesha Nashwa Talaat, Sirgel Frik A, Sola Christophe, Oliveira Sousa Erivelton, Streicher Elizabeth M, Helden Paul Van, Viveiros Miguel, Warren Robert M, McNerney Ruth, Pain Arnab, Clark Taane G
Abstract excerpt
To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mixed-regression framework was followed by a phylogenetics-based test for independent mutations. In addition to mutations in established and recently described...
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