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Regression for accurate and sensitive grading of mutations diagnostic of antibiotic resistance in<i>Mycobacterium tuberculosis</i>

2024-07-05

Abstract excerpt

Rapid genotype-based drug susceptibility testing for the Mycobacterium tuberculosis complex (MTBC) relies on a comprehensive knowledgebase of the genetic determinants of resistance. We built a catalog of resistance-associated mutations in MTBC using a novel regression-based approach and benchmarked it against the 2 nd edition of the World Health Organization mutation catalog. We trained multivariate logistic regre...

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Literature Corpus work
ad48ef75-541f-5298-ba43-7bdca9d41e9a
DOI
10.1101/2024.07.01.24309598
Open publication

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Regression for accurate and sensitive grading of mutations diagnostic of antibiotic resistance in<i>Mycobacterium tuberculosis</i>DOI 10.1101/2024.07.01.24309598
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