Back to search

Article

Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach

2023-10-02

Abstract excerpt

<title>Abstract</title><p>The World Health Organization has a goal of universal drug susceptibility testing for patients with tuberculosis; however, molecular diagnostics to date have focused largely on first-line drugs and predicting binary susceptibilities. We used a multivariable linear mixed model alongside whole genome sequencing and a quantitative microtiter plate assay to relate genomic mutations to minimum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5bcdfd26-389f-50c0-81a7-3b802868c583
DOI
10.21203/rs.3.rs-3378915/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approachDOI 10.21203/rs.3.rs-3378915/v1
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach.Semantic proximity
Quantitative measurement of antibiotic resistance in <i>Mycobacterium tuberculosis</i> reveals genetic determinants of resistance and susceptibility in a target gene approachSemantic proximity
Genome-wide association studies of global <i>Mycobacterium tuberculosis</i> resistance to thirteen antimicrobials in 10,228 genomesSemantic proximity
Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms.Semantic proximity
Genome wide association with quantitative resistance phenotypes in <i>Mycobacterium tuberculosis</i> reveals novel resistance genes and regulatory regionsSemantic proximity
Regression for accurate and sensitive grading of mutations diagnostic of antibiotic resistance in<i>Mycobacterium tuberculosis</i>Semantic proximity
Genomic Diagnostics for Drug-Resistant Mycobacterium tuberculosis: Computational Prediction of Antimicrobial ResistanceSemantic proximity
A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.Semantic proximity
GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions.Semantic proximity
Whole genome sequencing for drug resistance profile prediction in <i>Mycobacterium tuberculosis</i>Semantic proximity
An improved catalogue for whole-genome sequencing prediction of bedaquiline resistance in <i>M. tuberculosis</i> using a reproducible algorithmic approachSemantic proximity
Mycobacterium tuberculosis functional genetic diversity, altered drug sensitivity, and precision medicine.Semantic proximity
Select a neighboring publication to make it the new centre.