Comprehensive Analysis of the Human Urinary Peptidome Using Peptide Clustering Approach Reveals Age- and Gender-Specific Patterns

Abstract excerpt

<h4>Background</h4> The human urine peptidome reflects physiological and pathological states, making it a valuable resource for biomarker discovery. However, endogenous peptides often exist as cascades of truncated variants, complicating comparative analyses. To address this, we developed a “peptide cluster” approach, grouping overlapping peptides into representative clusters for robust statistical evaluation. <h4...

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• Access to Information
• Cell Adhesion Molecules Research
• Cholesterol
• Databases, Protein
• Docetaxel
• Internet
• Proteome
• RNA Splicing

Identifiers and source

Literature Corpus work

ac1b71af-4de4-5d3a-b770-28b1931a4fe7

DOI

10.1101/2025.05.16.25327757